Comments on Point:Counterpoint: Exercise-induced intrapulmonary shunting is imaginary vs. real
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Point:Counterpoint Comments Comments on Point:Counterpoint: Exercise-induced intrapulmonary shunting is imaginary vs. real IT’S TOO EARLY FOR THE SHUNT DEBATE
TO THE EDITOR: The issue whether shunt does (2) or does not (1) develop during exercise and whether shunt is responsible for the increased A-aDO2 seen in many people during exercise is developing into a methodological debate that will not be solved with the information available at this time. We do not know the in vivo bubble sizes in saline contrast echocardiography nor do we know the influenc...
متن کاملLast Word on Point:Counterpoint: Exercise-induced intrapulmonary shunting is imaginary vs. real.
Andrew T. Lovering, Marlowe W. Eldridge, and Michael K. Stickland University of Oregon, Department of Human Physiology, Eugene, Oregon; Department of Population Health Sciences, Department of Pediatrics, and Department of Biomedical Engineering, University of Wisconsin School of Medicine and Public Health, John Rankin Laboratory of Pulmonary Medicine, Madison, Wisconsin; Division of Pulmonary M...
متن کاملCounterpoint: Exercise-induced intrapulmonary shunting is real.
intrapulmonary shunt is miniscule is further confirmed by a recent study reporting venous admixture in very fit athletes during exercise breathing pure O 2 (18). During 100% oxygen breathing, alveolar PO 2 is elevated to such an extent that ventilation-perfusion inequality and diffusion limitation no longer contribute to the AaDO 2 —it can be explained only by right to left shunting (18). In th...
متن کاملExercise-induced intrapulmonary arteriovenous shunting in healthy humans.
We hypothesized that increasing exercise intensity recruits dormant arteriovenous intrapulmonary shunts, which may contribute to the widened alveolar-arterial oxygen difference seen with exercise. Twenty-three healthy volunteers (13 men and 10 women, aged 23-48 yr) with normal lung function and a wide range of fitness (mean maximal oxygen uptake = 126% predicted; range = 78-200% predicted) were...
متن کاملChanges in Intrapulmonary Shunting
We would like to offer the following comments concerning the interesting paper by Shapiro et al (Chest 1980; 77:138). Even though we agree, in general terms, with their statement that venous admixture ( va/Qt) should increase when a patient breathes 100 percent 02, measured either by Berggien’s classic methodl or with the inert gases technique,2 we have observed that it does not always do so be...
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ژورنال
عنوان ژورنال: Journal of Applied Physiology
سال: 2009
ISSN: 8750-7587,1522-1601
DOI: 10.1152/japplphysiol.00660.2009